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Formulation Development And Optimization

High-Throughput Absorption Depth Profiling in Stratum Corneum

High-Throughput Corneal/Scleral Absorption and Pentration Screening

High-Throughput In Vitro Release Testing (HT-IVRT)

High-Throughput Nail Penetration Screening

High-Throughput Screening of Compound Library for Topical and Transdermal Delivery

High-Throughput Skin Absorption and Penetration Screening

In Vitro Skin Barrier Integrity and Skin Irritation/Corrosion Test

Preformulation, design, Development, and Screening

Skin Absorption and Penetration Enhancement and Retardation Development

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High-Throughput Franz Cell Technology for Topical and Transdermal Formulation Screening - Innovative Technology, Unparalleled Service


Zyleris provides topical and transdermal formulation screening and development services.  Specifically, we provide high-throughput tissue (skin, nail, and ocular) absorption and penetration screening services.  Our first-in-class, proprietary high-throughput screening (HTS) platform was developed based on the industry standard Franz Cell principle.  It offers the best of both worlds - speed and cost efficiency associated with high-throughput experimentation and yet data compatibility with the Franz Cell technology.  We are committed to be your trusted partner in topical drug delivery and pharmaceutical product development.


  Proof-of-Concept (POC) Formulation Development and Evaluation Starter Package

If you need a quick and cost-effective answer about feasibility of topical delivery of your active compound(s), this POC starter package is the perfect solution for you.

In the package, we will develop 3-to-6 topical formulations in various dosage forms (e.g., cream, gel, ointment, or solution, etc.) and/or concentration levels.  Then, the formulations will be evaluated for skin absorption and penetration using our HTS platform.  Data from the POC study will confirm if topical delivery route is feasible and lay the ground work for future formulation development and optimization.  Typically, you will have the answer for you in about 4 weeks (from receipt of testing materials/APIs to delivery of project report - actual turnaround time, in most of cases, is sooner than the "typical" time).

 
 
 
News & Events
 
High-Throughput Screening of Compound Library for Topical and Transdermal Delivery

Zyleris PharmaTech (www.Zyleris.com) has announced the launch of a new drug...
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High-Throughput Formulation Screening Service for Topical and Transdermal Drug Development

Chicago, IL, U.S.A, July 26, 2010 – Zyleris PharmaTech (www.Zyleris.c...
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New Products & Services
 
Scientific Publications

1. Effect of 1,4-Cyclohexanediol on Percutaneous Absorption and Penetration...
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