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High-Throughput Absorption Depth Profiling in Stratum Corneum

High-Throughput Corneal/Scleral Absorption and Pentration Screening

High-Throughput In Vitro Release Testing (HT-IVRT)

High-Throughput Nail Penetration Screening

High-Throughput Screening of Compound Library for Topical and Transdermal Delivery

High-Throughput Skin Absorption and Penetration Screening

In Vitro Skin Barrier Integrity and Skin Irritation/Corrosion Test

Ophthalmic Formulation Development and Optimization

Preformulation, design, Development, and Screening

Skin Absorption and Penetration Enhancement and Retardation Development

Topical Formulation Development And Optimization

Your Partner in Topical Drug Delivery and Formulation Development

High-Throughput Franz Cell Technology for Topical Formulation Screening - Rapid Screening of Skin Absorption and Penetration of an API

Zyleris provides topical and transdermal formulation screening and development services.  Specifically, we provide high-throughput tissue (skin, nail, and ocular) absorption and penetration screening services.  Our first-in-class, proprietary, high-throughput screening (HTS) platform was developed based on the Franz Cell principle.  It offers the best of both worlds - speed, cost efficiency associated with high-throughput experimentation, and data compatibility with the industry standard Franz Cell technology.

In vitro Skin Absorption Screening Using 20-50 Donors

Skin absorption of an API is greatly dependent on an individual's skin.  This creates a wide variety of results in an in vivo study or clinical trial that cannot be captured by a typical in vitro study with a few donors.  Understanding these results is crucial to the success of a carefully crafted topical formulation.  Since a clinical trial or an in vivo study of a topical formulation typically involves 100 to 500 participants, an in vitro study with 20 to 50 donors can provide valuable insights about a formulation's behavior in a larger population.

With our high-throughput Franz Cell technology and large inventory of human skin tissues, Zyleris has the capability to perform such skin absorption screening quickly and cost-efficiently.

Screening configuration:

Number of donors: 20 to 50.  Number of replicates: 2 to 4.  Number of Franz Cell needed for the screening: 40 to 200 cells.

We routinely conduct skin absorption studies involving those many of Franz Cells.

Typical turnaround time: four-to-six weeks.

Our customizable service allows customers to select donors that match their target treatment group and determine the number of donors that best fits their needs.

News & Events
High-Throughput Formulation Screening Service for Topical and Transdermal Drug Development

Chicago, IL, U.S.A, July 26, 2010 – Zyleris PharmaTech (www.Zyleris.c...
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High-Throughput Screening of Compound Library for Topical and Transdermal Delivery

Zyleris PharmaTech ( has announced the launch of a new drug...
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New Products & Services
Scientific Publications

1. Effect of 1,4-Cyclohexanediol on Percutaneous Absorption and Penetration...
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