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High-Throughput Absorption Depth Profiling in Stratum Corneum

High-Throughput Corneal/Scleral Absorption and Pentration Screening

High-Throughput In Vitro Release Testing (HT-IVRT)

High-Throughput Nail Penetration Screening

High-Throughput Screening of Compound Library for Topical and Transdermal Delivery

High-Throughput Skin Absorption and Penetration Screening

In Vitro Skin Barrier Integrity and Skin Irritation/Corrosion Test

Ophthalmic Formulation Development and Optimization

Preformulation, design, Development, and Screening

Skin Absorption and Penetration Enhancement and Retardation Development

Topical Formulation Development And Optimization

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Your Partner in Topical Drug Delivery and Formulation Development


High-Throughput Franz Cell Technology for Topical Formulation Screening - Rapid Screening of Skin Absorption and Penetration of an API


Zyleris provides topical and transdermal formulation screening and development services.  Specifically, we provide high-throughput tissue (skin, nail, and ocular) absorption and penetration screening services.  Our first-in-class, proprietary, high-throughput screening (HTS) platform was developed based on the Franz Cell principle.  It offers the best of both worlds - speed, cost efficiency associated with high-throughput experimentation, and data compatibility with the industry standard Franz Cell technology.


In vitro Skin Absorption Screening Using 20-50 Donors


Skin absorption of an API is greatly dependent on an individual's skin.  This creates a wide variety of results in an in vivo study or clinical trial that cannot be captured by a typical in vitro study with a few donors.  Understanding these results is crucial to the success of a carefully crafted topical formulation.  Since a clinical trial or an in vivo study of a topical formulation typically involves 100 to 500 participants, an in vitro study with 20 to 50 donors can provide valuable insights about a formulation's behavior in a larger population.

With our high-throughput Franz Cell technology and large inventory of human skin tissues, Zyleris has the capability to perform such skin absorption screening quickly and cost-efficiently.

Screening configuration:

Number of donors: 20 to 50.  Number of replicates: 2 to 4.  Number of Franz Cell needed for the screening: 40 to 200 cells.

We routinely conduct skin absorption studies involving those many of Franz Cells.

Typical turnaround time: four-to-six weeks.

Our customizable service allows customers to select donors that match their target treatment group and determine the number of donors that best fits their needs.





 
 
 
News & Events
 
High-Throughput Screening of Compound Library for Topical and Transdermal Delivery

Zyleris PharmaTech (www.Zyleris.com) has announced the launch of a new drug...
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High-Throughput Formulation Screening Service for Topical and Transdermal Drug Development

Chicago, IL, U.S.A, July 26, 2010 – Zyleris PharmaTech (www.Zyleris.c...
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New Products & Services
 
Scientific Publications

1. Effect of 1,4-Cyclohexanediol on Percutaneous Absorption and Penetration...
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